- Title
- Serum 25 hydroxyvitamin d levels during pregnancy in women with asthma: Associations with maternal characteristics and adverse maternal and neonatal outcomes
- Creator
- Jensen, Megan E.; Camargo, Carlos A.; Harvey, Soriah M.; Gibson, Peter G.; Murphy, Vanessa E.
- Relation
- NHMRC.APP1084816 http://purl.org/au-research/grants/nhmrc/1084816 & APP455592 http://purl.org/au-research/grants/nhmrc/455592 & APP455593 http://purl.org/au-research/grants/nhmrc/455593
- Relation
- Nutrients Vol. 12, Issue 10, no. 2978, p. 1-12
- Publisher Link
- http://dx.doi.org/10.3390/nu12102978
- Publisher
- MDPI AG
- Resource Type
- journal article
- Date
- 2020
- Description
- Low 25-hydroxyvitamin D (25(OH)D) levels are common in pregnancy and associated with adverse maternal/neonatal outcomes. In pregnant women with asthma, this study examined the association of lifestyle- and asthma-related factors on 25(OH)D levels and maternal/neonatal outcomes by vitamin D status. Serum 25(OH)D was measured at 16 and 35 weeks gestation in women with asthma (n = 103). Body mass index (BMI), gestational weight gain (GWG), smoking status, inhaled corticosteroid (ICS) use, asthma control, airway inflammation, and exacerbations, and maternal/neonatal outcomes were collected. Baseline and change (Δ) in 25(OH)D were modelled separately using backward stepwise regression, adjusted for season and ethnicity. Maternal/neonatal outcomes were compared between low (25(OH)D < 75 nmol/L at both time points) and high (≥75 nmol/L at one or both time points) vitamin D status. Fifty-six percent of women had low vitamin D status. Obesity was significantly associated with lower baseline 25(OH)D (Adj-R2 = 0.126, p = 0.008); ICS and airway inflammation were not. Excess GWG and season of baseline sample collection were significantly associated with Δ25(OH)D (Adj-R2 = 0.405, p < 0.0001); asthma-related variables were excluded (p > 0.2). Preeclampsia was more common in the low (8.6%) vs. high (0%) vitamin D group (p < 0.05). Obesity and excess GWG may be associated with gestational 25(OH)D levels, highlighting the importance of antenatal weight management.
- Subject
- maternal nutrition physiology; vitamin d; pregnancy; asthma; maternal obesity; gestational weight gain; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1444616
- Identifier
- uon:42352
- Identifier
- ISSN:2072-6643
- Language
- eng
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